CONVENTIONAL THERAPIES DEPLETE BRAIN-INFILTRATING ADAPTIVE IMMUNE CELLS IN A MOUSE MODEL OF GROUP 3 MEDULLOBLASTOMA IMPLICATING MYELOID CELLS AS FAVORABLE IMMUNOTHERAPY TARGETS

Medulloblastoma is the most common childhood brain cancer.Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment Skewers approaches are crucial for the improvement of clinical outcomes.To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment o

The data demonstration article presented here showcases three months of wind speed field records for Khartoum city from June to August 2017.These records were obtained from the SOBA-D161094 meteorological mast Dishwasher Timer Knob station, located within the premises of the National Energy Research Center of Sudan.Using the two-parameter Weibull d

Kelvin KW Cheng, Andrew J Tatham Princess Alexandra Eye Pavilion, Edinburgh, UKCorrespondence: Andrew J TathamPrincess Alexandra Eye Pavilion, Edinburgh, UKTel +44 131 536 3753Email andrewjtatham@gmail.comAbstract: The disc damage likelihood scale (DDLS) is a tool for classifying glaucomatous structural changes to the optic disc based on the radial

Metformin is an old and widely accepted first-line drug for treating type 2 diabetes.Our previous studies demonstrate that metformin can stimulate the osteo/odontogenic differentiation of human-induced pluripotent stem cell-derived mesenchymal stem cells and human dental pulp cells (DPCs).Due to the rapid dilution of metformin from the defect area,

Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival and response to aggressive therapy.Limited access of drugs Dishwasher Timer Knob to tumor cells is one reason for such grim clinical outcomes.A driving force for therapeutic delivery is interstitial fluid flow (IFF), both within the tumor and i